Interaction of massive black hole binaries with their stellar environment: II. Loss-cone depletion and binary orbital decay

We study the long-term evolution of massive black hole binaries (MBHBs) at the centers of galaxies using detailed scattering experiments to solve the full three-body problem. Ambient stars drawn from a isotropic Maxwellian distribution unbound to the binary are ejected by the gravitational slingshot. We construct a minimal, hybrid model for the depletion of the loss cone and the orbital decay of the binary, and show that secondary slingshots - stars returning on small impact parameter orbits to have a second super-elastic scattering with the MBHB - may considerably help the shrinking of the pair in the case of large binary mass ratios. In the absence of loss-cone refilling by two-body relaxation or other processes, the mass ejected before the stalling of a MBHB is half the binary reduced mass. About 50% of the ejected stars are expelled ejected in a "burst" lasting ~1E4 yrs M_6^1/4, where M_6 is the binary mass in units of 1E6 Msun. The loss cone is completely emptied in a few bulge crossing timescales, 1E7 yrs M_6^1/4. Even in the absence of two-body relaxation or gas dynamical processes, unequal mass and/or eccentric binaries with M_6 >0.1 can shrink to the gravitational wave emission regime in less than a Hubble time, and are therefore "safe" targets for the planned Laser Interferometer Space Antenna (LISA).Comment: Minor revision. 10 pages, 7 figures, ApJ in pres

Late-Onset Cognitive Impairments after Early-Life Stress Are Shaped by Inherited Differences in Stress Reactivity

Early-life stress (ELS) has been associated with lasting cognitive impairments and with an increased risk for affective disorders. A dysregulation of the hypothalamus-pituitary-adrenal (HPA) axis, the body's main stress response system, is critically involved in mediating these long-term consequences of adverse early-life experience. It remains unclear to what extent an inherited predisposition for HPA axis sensitivity or resilience influences the relationship between ELS and cognitive impairments, and which neuroendocrine and molecular mechanisms may be involved. To investigate this, we exposed animals of the stress reactivity mouse model, consisting of three independent lines selectively bred for high (HR), intermediate (IR), or low (LR) HPA axis reactivity to a stressor, to ELS and assessed their cognitive performance, neuroendocrine function and hippocampal gene expression in early and in late adulthood. Our results show that HR animals that were exposed to ELS exhibited an HPA axis hyper-reactivity in early and late adulthood, associated with cognitive impairments in hippocampus-dependent tasks, as well as molecular changes in transcript levels involved in the regulation of HPA axis activity (Crh) and in neurotrophic action (Bdnf). In contrast, LR animals showed intact cognitive function across adulthood, with no change in stress reactivity. Intriguingly, LR animals that were exposed to ELS even showed significant signs of enhanced cognitive performance in late adulthood, which may be related to late-onset changes observed in the expression of Crh and Crhr1 in the dorsal hippocampus of these animals. Collectively, our findings demonstrate that the lasting consequences of ELS at the level of cognition differ as a function of inherited predispositions and suggest that an innate tendency for low stress reactivity may be protective against late-onset cognitive impairments after ELS

Unstable Disk Galaxies. II. the Origin of Growing and Stationary Modes

I decompose the unstable growing modes of stellar disks to their Fourier components and present the physical mechanism of instabilities in the context of resonances. When the equilibrium distribution function is a non-uniform function of the orbital angular momentum, the capture of stars into the corotation resonance imbalances the disk angular momentum and triggers growing bar and spiral modes. The stellar disk can then recover its angular momentum balance through the response of non-resonant stars. I carry out a complete analysis of orbital structure corresponding to each Fourier component in the radial angle, and present a mathematical condition for the occurrence of van Kampen modes, which constitute a continuous family. I discuss on the discreteness and allowable pattern speeds of unstable modes and argue that the mode growth is saturated due to the resonance overlapping mechanism. An individually growing mode can also be suppressed if the corotation and inner Lindblad resonances coexist and compete to capture a group of stars. Based on this mechanism, I show that self-consistent scale-free disks with a sufficient distribution of non-circular orbits should be stable under perturbations of angular wavenumber $m>1$. I also derive a criterion for the stability of stellar disks against non-axisymmetric excitations.Comment: 15 Pages (emulateapj), 7 Figures, Accepted for Publication in The Astrophysical Journa

Generic versus branded antiepileptic drug monotherapy for epilepsy

This protocol for a Cochrane Review is out of date and has been withdrawn in order to adhere to Cochrane policy. The editorial group responsible for this previously published document have withdrawn it from publication

A Learning-Based Framework for Safe Human-Robot Collaboration with Multiple Backup Control Barrier Functions

Ensuring robot safety in complex environments is a difficult task due to actuation limits, such as torque bounds. This paper presents a safety-critical control framework that leverages learning-based switching between multiple backup controllers to formally guarantee safety under bounded control inputs while satisfying driver intention. By leveraging backup controllers designed to uphold safety and input constraints, backup control barrier functions (BCBFs) construct implicitly defined control invariance sets via a feasible quadratic program (QP). However, BCBF performance largely depends on the design and conservativeness of the chosen backup controller, especially in our setting of human-driven vehicles in complex, e.g, off-road, conditions. While conservativeness can be reduced by using multiple backup controllers, determining when to switch is an open problem. Consequently, we develop a broadcast scheme that estimates driver intention and integrates BCBFs with multiple backup strategies for human-robot interaction. An LSTM classifier uses data inputs from the robot, human, and safety algorithms to continually choose a backup controller in real-time. We demonstrate our method's efficacy on a dual-track robot in obstacle avoidance scenarios. Our framework guarantees robot safety while adhering to driver intention

Orbits in Extended Mass Distributions: General Results and the Spirographic Approximation

This paper explores orbits in extended mass distributions and develops an analytic approximation scheme based on epicycloids (spirograph patterns). We focus on the Hernquist potential which provides a good model for many astrophysical systems, including elliptical galaxies, dark matter halos, and young embedded star clusters. For a given potential, one can readily calculate orbital solutions as a function of energy and angular momentum using numerical methods. In contrast, this paper presents a number of analytic results for the Hernquist potential and proves a series of general constraints showing that orbits have similar properties for any extended mass distribution (including, e.g., the NFW profile). We discuss circular orbits, radial orbits, zero energy orbits, different definitions of eccentricity, analogs of Kepler's law, the definition of orbital elements, and the relation of these orbits to spirograph patterns (epicycloids). Over much of parameter space the orbits can be adequately described (with accuracy better than 10%) using the parametric equations of epicycloids, thereby providing an analytic description of the orbits. As an application of this formal development, we find a solution for the orbit of the Large Magellanic Cloud in the potential of our Galaxy.Comment: 40 pages including 9 figures; accepted to The Astrophysical Journa

Methodological considerations in the analysis of fecal glucocorticoid metabolites in tufted capuchins (Cebus apella)

Analysis of fecal glucocorticoid (GC) metabolites has recently become the standard method to monitor adrenocortical activity in primates noninvasively. However, given variation in the production, metabolism, and excretion of GCs across species and even between sexes, there are no standard methods that are universally applicable. In particular, it is important to validate assays intended to measure GC production, test extraction and storage procedures, and consider the time course of GC metabolite excretion relative to the production and circulation of the native hormones. This study examines these four methodological aspects of fecal GC metabolite analysis in tufted capuchins (Cebus apella). Specifically, we conducted an adrenocorticotrophic hormone (ACTH) challenge on one male and one female capuchin to test the validity of four GC enzyme immunoassays (EIAs) and document the time course characterizing GC me- tabolite excretion in this species. In addition, we compare a common field-friendly technique for extracting fecal GC metabolites to an established laboratory extraction methodology and test for effects of storing “field extracts” for up to 1 yr. Results suggest that a corticosterone EIA is most sensitive to changes in GC production, provides reliable measures when extracted according to the field method, and measures GC metabolites which remain highly stable after even 12 mo of storage. Further, the time course of GC metabolite excretion is shorter than that described yet for any primate taxa. These results provide guidelines for studies of GCs in tufted capuchins, and underscore the importance of validating methods for fecal hormone analysis for each species of interest